Synthesis, Physicochemical, and Antimicrobial Activity of Copper and Zinc Complexes with N, O - Bidentate Schiff Base

This paper is intended to prepare new antimicrobial complexes with proven efficiency. The Schiff base, through the condensation process of salicylaldehyde and p-toludine, its Cu Zn were successfully synthesized. base characterized using molar conductivity, Ultraviolet-visible (UV-Vis), atomic absorption spectroscopy (AAS), Fourier transform infrared (FTIR) techniques. Accordingly, these characterizations not only confirmed that synthesized acted as N,O bidentate ligand (through azomethine nitrogen phenoxide oxygen) chelated Cu(II) Zn(II) in metal-to-ligand ratio 1:2 but also revealed characteristic electronic-transition π→π*/n→π* ligand, ligand-metal charge transfer d-d metal complexes. Moreover, both recorded weak conductance 54.12 51.41 S cm2 mol-1, respectively. Further, their antibacterial activities evaluated by disc diffusion assay against Staphylococcus aureus (gram-positive), Escherichia coli (gram-negative), Bacillus cereus (gram-negative) bacteria. For all microbial, higher than parent ligand; such increased activity may be due chelation ion complexes, which enhances lipophylic character favoring permeation lipid layer cell membrane. Such can therefore explored future an option for decreasing pathogenic potential infecting